Protein folding taking shape

Protein folding taking shape

A EuroConference/EMBO workshop on molecular chaperones was held May 26–31, 2001, at Sant Feliu de Guixols, Spain, drenched in the sunshine of the Costa Brava with Salvador Dali’s last home and a museum of his work close at hand. Suitably, the cover of the abstract book displayed a detail from one of Dali’s works, featuring a fried egg hanging by its neck. The meeting covered quite a spectrum of...

SHAPE directed RNA folding

SUMMARY Chemical mapping experiments allow for nucleotide resolution assessment of RNA structure. We demonstrate that different strategies of integrating probing data with thermodynamics-based RNA secondary structure prediction algorithms can be implemented by means of soft constraints. This amounts to incorporating suitable pseudo-energies into the standard energy model for RNA secondary struc...

Protein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions

Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...

Cell Shape: Taking the Heat

Preservation of cell architecture under physically stressful conditions is a basic requirement for many biological processes and is critical for mechanosensory systems built to translate subtle changes in cell shape into changes in organism behaviour. A new study reveals how an extracellular protein--Spam--helps mechanosensory organs in the fruit fly to withstand the effects of the water loss t...

Folding any 3 D shape